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Saturday, May 8, 2021

Some COVID19 VAX_TYPE VAERS data and analysis: 05.07.2021

Some VAERS snapshots analysis from the Friday, 05/07/2021 VAERS drop (updated to 04/30/2021). These tables and charts are produced with R packages (libraries) from CRAN and Bioconductor including data.table, tm, graph, Rgraphviz, wordcloud. Post under construction. Click to enlarge the jpgs.

Thursday, April 15, 2021

Monday, April 12, 2021

Lattice and Bar chart graphs of Cases and Deaths for all U.S. states and territories from 01.01.2020 - 04.12.21

Below the break find lattice and bar chart graphs of cases and deaths for all U.S. states and territories from 01.01.2020 -  04.12.21. Read lattice charts top to bottom over time. Read bar charts left to right over time. Data from CDC Cases and Deathshttps://data.cdc.gov/Case-Surveillance/United-States-COVID-19-Cases-and-Deaths-by-State-o/9mfq-cb36 Abbreviations for  U.S. territories are:

Territory Abbreviations:
American Samoa   AS
Federated States
of Micronesia    FSM 
Guam GU
Marshall Islands MH
Northern Mariana
Islands  MP
Palau PW
Puerto Rico PR
Virgin Islands   VI

Tuesday, March 16, 2021

03.15.2021 Update: Successful Mass Vaccinations or Mass Deaths?

 "The vast majority of V2 and V3 variants and some more recent V1 variants also have a spike E484K mutation. Whereas in the presence of 501N, 484K has a modest positive impact on ACE2 binding 9, when present with 501Y, these mutations together synergistically increase ACE2-RBD binding affinity ~12.7 fold ... Crucially, E484K and other mutations at S/484 also frequently confer protection from neutralization by both convalescent sera ... , vaccine elicited antibodies ... , and some monoclonal antibodies ... There is therefore increasing evidence that viruses carrying the E484K mutation (with or without 501Y) will be able to more frequently infect both previously infected ... and vaccinated individuals ..." 

"The most important issue here is not whether this particular 'super variant' ever arises, but rather that the convergent mutations that have already arisen in members of the different 501Y lineages implies that these viruses are presently on, and are actively scaling, a broad new peak in the fitness landscape. Whatever SARS-CoV-2 variants eventually summit that peak could be a considerably bigger problem for us than any variants that we currently know in that they might have any combinations of increased transmissibility, altered virulence and/or increased capacity to escape population immunity."

"The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape" https://www.medrxiv.org/content/10.1101/2021.02.23.21252268v2 

Thursday, January 7, 2021

Update on thoughts on mask tech and mask use

I don't know how much my general thoughts on mask use for the general public have really changed in the last six months. I suspect the Swedish stance (https://www.reuters.com/article/us-health-coronavirus-sweden-cases/sweden-says-no-need-for-face-masks-as-covid-19-deaths-top-7000-idUSKBN28D1TH) on mask use is probably still being followed in many countries like Sweden, Norway, New Zealand. Immediately below there are some links to some earlier articles I wrote on mask use for the general public and farther below that are some new thoughts I have had on the new 'Covid-19 killing' mask tech: 

In line with the results of Danish RCT study (https://www.acpjournals.org/doi/full/10.7326/M20-6817), I doubt whether most current mask or 'face covering' use by the general public is actually slowing the spread of Covid-19 in the United States. But I think if you are going to wear a mask in the general public, you should take advantage of the latest tech in masks. Some have suggested N95 or KN95 lines of mask because they are now more available. Without a doubt approved N95 masks, if you can buy or afford them, can provide high levels of protection if fitted correctly. 

Personally, I find 3M N95 masks are excellent to wear while cleaning your heating system, vacuuming your garage, sweeping the patio. But I think it is improbable that the general public will don the tight fitting N95s as they pull masks in and out of their pockets between storefronts. What is more intriguing to me are the advances in 'germ killing' masks whose design appears to take into consideration the contamination dangers of most 'mask for the general public' usage.  Google "masks that kill Covid-19" for more information. 

CNN has a long article on this here: https://www.cnn.com/style/article/antimicrobial-fashion-coronavirus/index.html.  An article on designing better masks is here: https://hbr.org/2020/06/we-need-better-masks . These two vendors below are selling masks they claim can kill Covid-19 on contact: 

Here is the big problem I have with my mask use:  Many of those of us with Asthma (reputedly some ~25M or 1 out of every 13 in the US - see https://www.aafa.org/asthma-facts) simply can't breathe well with masks on. The snot, flem and the moisture start to pile up inside the mask which really invalidates the effectiveness of the mask and quite possibly makes a face mask a dangerous harbor of bacteria and a possible infection source; although about this danger is some debate. 

If you are going to use a face mask, you should at least follow the CDC recommendations here: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/how-to-wear-cloth-face-coverings.html. Depending on your budget, I would recommend having some number of high quality, comfortable masks that work for you so you can get through the week without washing or reusing old or unclean masks.