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Saturday, May 8, 2021

Some COVID19 VAX_TYPE VAERS data and analysis: 05.07.2021

Some VAERS snapshots analysis from the Friday, 05/07/2021 VAERS drop (updated to 04/30/2021). These tables and charts are produced with R packages (libraries) from CRAN and Bioconductor including data.table, tm, graph, Rgraphviz, wordcloud. Post under construction. Click to enlarge the jpgs.

Thursday, April 15, 2021

Monday, April 12, 2021

Lattice and Bar chart graphs of Cases and Deaths for all U.S. states and territories from 01.01.2020 - 04.12.21

Below the break find lattice and bar chart graphs of cases and deaths for all U.S. states and territories from 01.01.2020 -  04.12.21. Read lattice charts top to bottom over time. Read bar charts left to right over time. Data from CDC Cases and Deathshttps://data.cdc.gov/Case-Surveillance/United-States-COVID-19-Cases-and-Deaths-by-State-o/9mfq-cb36 Abbreviations for  U.S. territories are:

Territory Abbreviations:
American Samoa   AS
Federated States
of Micronesia    FSM 
Guam GU
Marshall Islands MH
Northern Mariana
Islands  MP
Palau PW
Puerto Rico PR
Virgin Islands   VI

Tuesday, March 16, 2021

03.15.2021 Update: Successful Mass Vaccinations or Mass Deaths?

 "The vast majority of V2 and V3 variants and some more recent V1 variants also have a spike E484K mutation. Whereas in the presence of 501N, 484K has a modest positive impact on ACE2 binding 9, when present with 501Y, these mutations together synergistically increase ACE2-RBD binding affinity ~12.7 fold ... Crucially, E484K and other mutations at S/484 also frequently confer protection from neutralization by both convalescent sera ... , vaccine elicited antibodies ... , and some monoclonal antibodies ... There is therefore increasing evidence that viruses carrying the E484K mutation (with or without 501Y) will be able to more frequently infect both previously infected ... and vaccinated individuals ..." 

"The most important issue here is not whether this particular 'super variant' ever arises, but rather that the convergent mutations that have already arisen in members of the different 501Y lineages implies that these viruses are presently on, and are actively scaling, a broad new peak in the fitness landscape. Whatever SARS-CoV-2 variants eventually summit that peak could be a considerably bigger problem for us than any variants that we currently know in that they might have any combinations of increased transmissibility, altered virulence and/or increased capacity to escape population immunity."

"The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape" https://www.medrxiv.org/content/10.1101/2021.02.23.21252268v2