Rapamycin is in the Long Covid, ME/CFS news:
- https://gethealthspan.com/science/article/rapamycin-treatment-for-long-covid
- https://polybio.org/projects/long-covid-low-dose-rapamycin-clinical-trial/
- https://www.healthrising.org/blog/2025/02/01/simmarons-rapamycin-chronic-fatigue-fda-approval/
I did a semi-deep dive. Information and links below:
General information on Macrolides and mTOR
- https://en.wikipedia.org/wiki/MTOR
- https://en.wikipedia.org/wiki/MTOR_inhibitors
- https://pubmed.ncbi.nlm.nih.gov/34065929/ Macrolides: From Toxins to Therapeutics
- https://www.wikidoc.org/index.php/Macrolide
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3432395/ Macrolide Therapy in Chronic Inflammatory Diseases
- https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/macrolide Macrolide
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5573421/ The macrolide antibiotic renaissance
Rapamycin and Rapalogs
- https://www.sciencedirect.com/topics/medicine-and-dentistry/rapamycin Rapamycin
- https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00215 Rapalogs Potential as Practical Alternatives to Rapamycin
- https://karger.com/ger/article/69/6/657/836027/Why-Is-Rapamycin-Not-a-Rapalog Why Is Rapamycin Not a Rapalog
Anti-aging components of Rapamycin and Rapalogs
- https://aging-matters.com/mtor-inhibitors-in-cancer-health-and-aging/ mTOR inhibitors in cancer, health and aging
- https://pubmed.ncbi.nlm.nih.gov/23454761/ Rapalogs and mTOR inhibitors as anti-aging therapeutics
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3582126/ Rapalogs and mTOR inhibitors as anti-aging therapeutics
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5482593/ From rapalogs to anti-aging formula
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5061789/ New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation
Rapalogs as Cancer Therapy
- https://www.med.unc.edu/microimm/dittmerlab/wp-content/uploads/sites/606/2018/03/Rapalogs-in-viral-cancers.pdf
- https://www.nature.com/articles/aps201568 Toward rapamycin analog (rapalog)-based precision cancer therapy
- https://www.news-medical.net/news/20230418/Rapamycin-and-other-rapalogs-have-potential-to-delay-cancer.aspx Rapamycin and other rapalogs have potential to delay cancer
- https://academic.oup.com/oncolo/article/29/Supplement_1/S19/7727915?login=false 21 Unconventional mechanisms of action and resistance to rapalogs in renal cancer
Using (or not) Rapalogs to Defeat Covid-19
- https://www.sciencedirect.com/science/article/pii/S2666756820300684 The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19
- https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30068-4/fulltext The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19
- https://www.sciencedirect.com/science/article/pii/S1359644621004803 The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19
- https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/ddr.21895 Races of small molecule clinical trials for the Treatment of Covid-19...
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8057238.2/ Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7272823/ Immunoregulation with mTOR inhibitors to prevent COVID‐19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8225252/ mTOR: A possible therapeutic target against SARS-CoV-2 infection
Discussion of Rapalog supplements
- https://www.google.com/search?q=What+supplements+inhibit+mTOR%3F "What supplements inhibit mTOR" (Gemini)
- https://search.brave.com/search?q=What+supplements+inhibit+mTOR%3F "Whatsupplements inhibit mTOR" (Leo)
- https://www.amazon.com/Supersmart-Rapalogs-Standardized-Inhibitors-Vegetarian/dp/B00LPJKUOG
- https://www.supersmart.com/en/shop/anti-ageing/natural-rapalogs-supplement-0655
- https://www.lifeextension.com/magazine/2021/2/senolytics
- https://www.lifeextension.com/search#q=removal%20of%20senescent%20cells
- http://www.ncbi.nlm.nih.gov/pubmed/25832358 A Novel Quinoline Based Second-generation mTOR Inhibitor that Induces Apoptosis and Disrupts PI3K-Akt-mTOR Signaling in Human Leukemia HL-60 Cells
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