Macrolides, mTOR, Rapamycin, Rapalogs

Rapamycin is in the Long Covid, ME/CFS news:

• https://gethealthspan.com/science/article/rapamycin-treatment-for-long-covid
• https://polybio.org/projects/long-covid-low-dose-rapamycin-clinical-trial/
• https://www.healthrising.org/blog/2025/02/01/simmarons-rapamycin-chronic-fatigue-fda-approval/ 

I did a semi-deep dive. Information and links below:

General information on Macrolides and mTOR

• https://en.wikipedia.org/wiki/MTOR
• https://en.wikipedia.org/wiki/MTOR_inhibitors
• https://pubmed.ncbi.nlm.nih.gov/34065929/ Macrolides: From Toxins to Therapeutics
• https://www.wikidoc.org/index.php/Macrolide
• https://pmc.ncbi.nlm.nih.gov/articles/PMC3432395/ Macrolide Therapy in Chronic Inflammatory Diseases   
• https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/macrolide Macrolide
• https://pmc.ncbi.nlm.nih.gov/articles/PMC5573421/  The macrolide antibiotic renaissance

Rapamycin and Rapalogs

• https://www.sciencedirect.com/topics/medicine-and-dentistry/rapamycin Rapamycin
• https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00215 Rapalogs Potential as Practical Alternatives to Rapamycin
• https://karger.com/ger/article/69/6/657/836027/Why-Is-Rapamycin-Not-a-Rapalog Why Is Rapamycin Not a Rapalog

Anti-aging components of Rapamycin and Rapalogs

• https://aging-matters.com/mtor-inhibitors-in-cancer-health-and-aging/ mTOR inhibitors in cancer, health and aging
• https://pubmed.ncbi.nlm.nih.gov/23454761/ Rapalogs and mTOR inhibitors as anti-aging therapeutics
• https://pmc.ncbi.nlm.nih.gov/articles/PMC3582126/ Rapalogs and mTOR inhibitors as anti-aging therapeutics
• https://pmc.ncbi.nlm.nih.gov/articles/PMC5482593/ From rapalogs to anti-aging formula
• https://pmc.ncbi.nlm.nih.gov/articles/PMC5061789/ New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation

Rapalogs as Cancer Therapy

• https://www.med.unc.edu/microimm/dittmerlab/wp-content/uploads/sites/606/2018/03/Rapalogs-in-viral-cancers.pdf 
• https://www.nature.com/articles/aps201568 Toward rapamycin analog (rapalog)-based precision cancer therapy
• https://www.news-medical.net/news/20230418/Rapamycin-and-other-rapalogs-have-potential-to-delay-cancer.aspx  Rapamycin and other rapalogs have potential to delay cancer
• https://academic.oup.com/oncolo/article/29/Supplement_1/S19/7727915?login=false 21 Unconventional mechanisms of action and resistance to rapalogs in renal cancer

Using (or not)  Rapalogs to Defeat Covid-19

• https://www.sciencedirect.com/science/article/pii/S2666756820300684 The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19
• https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30068-4/fulltext The potential of rapalogs to enhance  resilience against SARS-CoV-2 infection and reduce the severity of COVID-19
• https://www.sciencedirect.com/science/article/pii/S1359644621004803 The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19
• https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/ddr.21895 Races of small molecule clinical trials for the Treatment of Covid-19...
• https://pmc.ncbi.nlm.nih.gov/articles/PMC8057238.2/ Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2
• https://pmc.ncbi.nlm.nih.gov/articles/PMC7272823/ Immunoregulation with mTOR inhibitors to prevent COVID‐19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines
• https://pmc.ncbi.nlm.nih.gov/articles/PMC8225252/ mTOR: A possible therapeutic target against SARS-CoV-2 infection

Discussion of Rapalog supplements

• https://www.google.com/search?q=What+supplements+inhibit+mTOR%3F "What supplements inhibit mTOR" (Gemini)
• https://search.brave.com/search?q=What+supplements+inhibit+mTOR%3F "Whatsupplements inhibit mTOR" (Leo)
• https://www.amazon.com/Supersmart-Rapalogs-Standardized-Inhibitors-Vegetarian/dp/B00LPJKUOG
• https://www.supersmart.com/en/shop/anti-ageing/natural-rapalogs-supplement-0655
• https://www.lifeextension.com/magazine/2021/2/senolytics
• https://www.lifeextension.com/search#q=removal%20of%20senescent%20cells
• http://www.ncbi.nlm.nih.gov/pubmed/25832358 A Novel Quinoline Based Second-generation mTOR Inhibitor that Induces Apoptosis and Disrupts PI3K-Akt-mTOR Signaling in Human Leukemia HL-60 Cells